Extended Spectrum Beta-Lactamase (ESBL)

Abstract

Antibiotics have been widely used today. Use of antibiotics is also often used in mass
and not in accordance with the indication, among others, in a particular case of fish
poisoning on the beach, often the treatment is given antibiotics without clearly
indication. Use of antibiotics are excessive and not in accordance with the clinical, can
cause resistance to these antibiotics
One of the antibiotics used is a beta-lactam antibiotic, that works inhibits cell walls.
The inappropriate use of beta-lactam antibiotics can lead to resistance to these
antibiotics. Resistance to beta-lactam can occur at various levels. One of the resistances
can occur is resistance to Extended Spectrum Broad Lactamase (ESBL)
Extended spectrum beta-lactamase is an enzyme that has the ability to hydrolyze
penicillin-type antibiotics, first-generation cephalosporins, two, and three as well as
monobactam groups and cause resistance throughout the antibiotic.
ESBL is produced by many Enterobactericeae (especially Escherichia coli) and
Klebsiella pneumoniae. Enterobacteriaceae has 3 resistance patterns caused by broadspectrum beta-lactamase, beta-lactamase-resistant inhibitors (TEM derivatives),
excessive cephalosporinase. ESBL can be difficult to detect because ESBL has
differentiatedactivity to various cephalosporins
ESBL can be detected in clinical microbiology (phenotypic) and molecular detection
(genotypic)