Oceana Biomedicina Journal

the UJI EFEKTIVITAS TABLET EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL PADA HEWAN MENCIT JANTAN PUTIH (Mus

gina lestari — 2024-01-31

Introduction : Binahong leaf (Anredera cordifolia (Ten.) Steenis) is a plant which is actually a wild plant. Sungkai leaves contain flavonoids, alkaloids, tannins, triterpenoids, saponins. This study aims to determine the effectiveness of Binahong leaf ethanol extract tablets (Anredera cordifolia (Ten.) Steenis) on blood cholesterol levels in male mice (Mus musculus).

Methodes: This research is an experimental research using the Easy Touch Glucose Cholesterol Uric Acid (GCU) checking method. Thirty male white mice were divided into 6 treatment groups, namely the Normal control group, Positive control, Negative control, F1 group, F2 group, and F3 group. Where mice were measured for blood cholesterol levels on day 1 as normal cholesterol, then their cholesterol levels were raised by feeding high cholesterol quail egg yolks for 7 days then checking the blood cholesterol of mice, after that it was lowered by being treated with Binahong Leaf Extract Tablets for 7 days then checked again mice blood cholesterol.

Results: The research results were analyzed using one-way ANOVA (p> 0.05) which was then tested by the Duncan showing that Binahong Leaf Extract Tablets at F3 doses of 14 mg with a reduction percentage of 20.64% had effectiveness in reducing blood cholesterol levels in male mice (Mus Musculus).

Conclusion : Binahong Leaf Extract Tablets have a buffer effect on reducing total cholesterol levels in mice

Indonesia

Dian Novita — 2024-01-31

Latar Belakang: Meningioma merupakan tumor intrakranial yang paling sering terjadi pada orang dewasa. Progesteron berperan dalam perkembangan dan proliferasi sel tumor yang terkait dengan hormon, seperti meningioma. Morbiditas dan mortalitas yang signifikan dapat terjadi, ketika lesi terlokalisasi di daerah yang sulit untuk dilakukan reseksi bedah atau sangat infiltratif pada jaringan di sekitarnya. Banyak penelitian yang dipublikasikan tentang sifat molekuler yang terkait dengan perilaku agresif meningioma, termasuk matrix metalloproteinase (MMP), namun penelitian tentang hubungan antara ekspresi PR dengan MMP-9 masih belum banyak dilakukan.

Metode : Penelitian ini menggunakan desain penelitian observasional analitik cross sectional. Analisis yang digunakan dalam penelitian ini meliputi analisis deskriptif dan analisis bivariat. Data yang diperoleh diolah menggunakan SPSS software.

Hasil : Uji korelasi Spearman untuk ekspresi PR dengan grading WHO pada meningioma, didapatkan nilai p=0,492 dan koefisien korelasi -0.117. Hal ini menunjukkan korelasi yang tidak bermakna. Uji korelasi Spearman untuk ekspresi MMP dengan grading WHO pada meningioma, didapatkan nilai p=0,16 dan koefisien korelasi 0.236. Hal ini menunjukkan korelasi yang tidak bermakna. Uji korelasi Spearman antara ekspresi MMP9 dan grading WHO pada meningioma diperoleh nilai p=0.008 yang menunjukkan bahwa korelasi antara nilai PR dengan MMP9 bermakna dengan nilai korelasi sebesar -0.427.

Kesimpulan : Tidak terdapat korelasi yang signifikan antara ekspresi PR dengan grading WHO. Tidak terdapat korelasi yang signifikan antara ekspresi MMP9 dengan grading WHO. Terdapat korelasi yang signifikan antara ekspresi PR dengan MMP9.

GAMBARAN PENGETAHUAN DAN EVALUASI CARA PENGGUNAAN INSULIN PEN PASIEN DIABETES MELLITUS DI RUMAH SAKIT BHAYANGKARA POLDA BENGKUL

Setya Enti Rikomah — 2024-01-31

Treatment for diabetes with insulin is given using an insulin pen. Pen insulin can be used alone by
the patient without requiring trained personnel. The patient's incomprehension in carrying out therapy is
one of the causes of therapy failure, due to the lack of knowledge and understanding of the patient
about the drug, everything related to the use of drugs for treatment.
The purpose of the study was to determine the knowledge based on the characteristics of
respondents, evaluation of insulin use pen, injection area, storage area, side effects. The study was
conducted by distributing questionnaires as primary data and sampling using purposive sampling
method. Respondents were patients with diabetes mellitus who used insulin pen in poly disease in
Bhayangkara Hospital. Data processed descriptively displayed with tables and graphs.
The results of the study were respondents with good knowledge, namely undergraduate 10
respondents (15.87%), civil servants and other jobs (pensioners, irt, students) each of 9 respondents
(14.29%), women15 respondents (23.81%), age 18 - 65 years 19 respondents (30.61%). Fast action
insulin and combination of 17 respondents (26.98%), novorapid 15 respondents (23.81%), no oral
drugs 44 respondents (69.84%), frequency 2 times a day, novomix 14 respondents (22 , 22%), 10-15
units 13 respondents (20.63%), insulin use> 1 year 27 respondents (42.86%), did not cause symptoms
57 respondents (90.48%). The use of the abdominal and arm areas of 23 respondents (35.51%),
storing in the refrigerator 32 respondents (50.79%), did not cause side effects 58 respondents (92.07%)

DIFFERENCES OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN VARIOUS MENINGIOMA EDEMA INDEX

puspa agrina — 2024-01-31

Background: Meningiomas are the most common primary intracranial tumor in adults after glioma. Vascular endothelial growth factor (VEGF) is a key protein in the formation of new blood vessels (angiogenesis). In meningiomas, binding of VEGF to the VEGF receptor (VEGFR) through activation of the Ras/MAPK signaling pathway and control of vascular permeability through the PLCγ pathway peritumoral (PTBE). Sixty percent of meningiomas are associated with peritumoral brain edema (PTBE).

Objective: This study aims to determine differences in VEGF expression on various indices of meningioma edema.

Methods: An analytical observational study with consecutive sampling in 69 samples diagnosed with meningioma with MRI data. VEGF expression variables based on Immunohistochemistry were classified into scores of 0, 1+ and 2+. Variable PTBE Meningiomas assessed by the edema index based on MRI were classified into grades 1,2 and 3.

Results: Based on Spearman's correlation test, there was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).

Conclusion: There was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).

Laporan Kasus : Oklusi Arteri Retina Sentra

Bertha Arviani Sugianto — 2024-01-31

Abstract
Central retinal artery occlusion is an occlusion that occurs suddenly in the
central retinal artery, which causes hypoperfusion of the retina, progressive cellular
damage, and loss of visual acuity. Risk factors are similar to other thromboembolic
diseases and include hypertension, smoking, hyperlipidemia, diabetes,
hypercoagulability, and male gender. All therapy for central retinal artery occlusion
aims to restore perfusion or oxygenation of the retina. Management for acute central
retinal artery occlusion can only be effective if performed less than 6 hours after
symptoms.
41-year-old woman, came to the Retina Eye Polyclinic, Surabaya Community
Eye Hospital with complaints of sudden blurring of the right eye since 3 days ago. On
examination of the anterior segment of the right eye, relative afferent pupillary defect
was found and on the posterior segment of the right eye, pale retina and cherry red
spot was found. Timolol, artificial tears, and eye supplement was given but did not give
good results

ANALISIS FITOKIMIA SENYAWA FLAVONOID DARI EKSTRAK ETANOL DAUN KENIKIR (Cosmos caudatus Kunth.) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-Vis

yuska noviyanty — 2024-01-31

Daun Kenikir (Cosmos caudatus Kunth.) merupakan tumbuhan yang berkhasiat obat yang sering dijumpai dilingkungan sekitar, serta merupakan tanaman yang sering dikonsumsi, telah dilakukan penelitian analisis fitokimia senyawa flavonoid dari ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) Menggunakan metode spektrofotometri UV-Vis Penelitian ini bertujuan untuk mengetahui kandungan senyawa flavonoid

Simplisia diekstraksi dengan metode maserasi dengan etanol 96%, kemudian dilakukan identifikasi senyawa flavonoid dengan penambahan serbuk Mg dan HCl pekat dan dilanjutkan dengan uji Penegasan kromatografi lapis tipis. Selanjutnya dilakukan Penetapan kadar ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) dengan metode spektrofotometri UV-Vis

Hasil Identifikasi yang didapatkan bahwa ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) positif mengandung senyawa flavonoid dilihat dari perubahan warna jingga hingga merah. Hasil kromatografi lapis tipis didapatkan nilai Rf rata-rata 0,78 dengan bercak noda berwarna kuning kehijauan dinyatakan positif mengandung senyawa flavonoid. Hasil penetapan kadar ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) dengan metode spektrofotometri UV-Vis didapatkan kadar sebesar 4,203% Senyawa flavonoid yang terkandung diketahui memiliki aktivitas antioksidan yang dapat mengurangi resiko penyakit kanker, peradangan hingga antibakteri.

Analysis Of Water Mimosa (Neptunia Plena (L.) Benth.) Density As Water Pollution Level Bioindicators In Jalan Karya Baru, Palembang, South Sumatra

Fitri Fitri — 2024-01-31

One of commonly found flora in swamps is water mimosa (Neptunia plena (L.) Benth.). Swamp is low land ecological system filled with standing water. This study aims to measure approximate water pollution level based on water mimosa (Neptunia plena (L.) Benth.) density using biometering to be used as public information to maintain and manage swamp water quality. This study showed dissolved oxygen content was 23.6, 24.64, and 25.05 at Station I, II, and III respectively. The pH at Station I, II, and III was 6.48, 6.50, and 6.47 respectively. The clarity was 0.18 m, 0.47 m, and 1.12 m at Station I, II, and III respectively, averaging at 0.59 m. Highest depth was observed at Station II (2.2 m), while lowest depth was observed at Station I (1.5 m).

bserved at Station

PENGARUH POLA DIET MENGONSUMSI IKAN LAUT TERHADAP FUNGSI KOGNITIF LANSIA

Elizabeth Natasya Harijawan — 2024-01-31

BACKGROUND Along with advances in technology, economy and health, the life expectancy of the world's population tends to increase. This has an impact on increasing the number of elderly (old) population. Aging is a natural process experienced by every human being and has been going on since the beginning of life. The aging process involves various physical multidimensional changes so it is a complex process. Includes mental, social, spiritual and physical changes. Changes in this mental aspect have an impact on cognitive function decline. A number of efforts can be made to inhibit the progression of the rate of decline in cognitive function, one of which is a good diet.

METHODS A study of 17 research articles from accredited and reputable international journals was conducted to study the effect of dietary patterns of consuming marine fish on the cognitive function of the elderly.

RESULTS Diet pattern has an effect on the cognitive function of the elderly. The Mediterranean diet pattern, consumption of wine, nuts, fruits, vegetables, protein foods, and seafood was correlated with lower cognitive decline, while the Western diet was associated with higher cognitive decline. Dietary patterns of consuming marine fish are associated with lower levels of cognitive decline in the elderly.

CONCLUSIONS Good dietary patterns, such as the Mediterranean diet and consumption of marine fish, are correlated with lower rates of cognitive decline in the elderly.

The Role of Metformin on the Expression of Apoptosis-Related Caspase Family Members

Rian Ka Praja — 2024-01-31

Metformin is the main line drug in the treatment of type 2 diabetes mellitus. However, now metformin has
been widely studied for its potential for the treatment of various diseases. Apoptosis is a programmed
cell death mechanism mediated by various proteins from the caspase family. Furthermore, the apoptotic
caspases are subdivided into the initiators (caspase-2, -8, -9, and -10) and the effectors (caspase-3, -6,
and -7). Various studies have reported that metformin could induce apoptosis, while other studies have
reported otherwise. This study aimed to reveal the role of metformin on the expression of caspase
proteins associated with apoptosis. Bioinformatics analysis using STITCH v.5.0 was performed to predict
the metformin-caspase interactions. The results showed that metformin could directly activate caspase3 and -7. However, at the same time, metformin could also inhibit the expression of caspase-3 and -8.
Furthermore, metformin did not interact directly with caspases -2, -6, -9, and -10. Through this study, it
can be concluded that metformin has dual roles (activation and inhibition) in the expression of apoptosisrelated caspase proteins.

DEDIFFERENTIATED LEIOMYOSARCOMA

Anggie Sasmita Kharisma Putri — 2024-01-31

ABSTRACT
BACKGROUND : Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma that ranges
from 7-10% of all cases of soft tissue sarcoma, usually occurring in adult and elderly
patients.
CASE REPORT : Patient Mr. M, male, 71 years old, construction worker, Tulungagung
Regency. The patient has a main complaint, namely a lump under the right armpit, felt since
2 months before visiting dr. Iskak Tulungagung.
DISCUSSION : Pleomorphic LMS or dedifferentiated LMS shows nonspecific and poorly
differentiated pleomorphism. To make this diagnosis, the characteristic morphological
features of classic LMS must be obtained, or the patient must have a prior history of LMS.
On immunohistochemistry, approximately 50–75% of pleomorphic LMS are positive for at
least one myogenic marker, although the smear is often weaker and more focal than in a
typical area of leiomyosarcoma.
CONCLUSION: Microscopically, the morphological appearance of dedifferentiated LMS
can resemble the appearance of other high-grade sarcomas, so clinical, radiological,
histopathological considerations and further examinations such as immunohistochemical
smears are needed.