THYROTOXICOSIS IN PATIENTS WITH HYDATID MOLE
DOI:
https://doi.org/10.30649/obj.v4i1.57Keywords:
Mola hydatodosa, HCG, TSH, sFlt1Abstract
Hydatid Mole, also often called grape pregnancy, is a pregnancy characterized by abnormal
trophoblast development. The incidence of hydatidiform mole per 1,000 pregnancies occurs in Asia. In
Indonesia, in 2002 cases of hydatidiform mole were found 1: 123 pregnancy, and in 2003 found cases of
hydatidiform mole 1: 245 pregnancy. While the results of research conducted in the same place in 2012-2013
obtained 39 cases of hydatidiform mole that were distributed based on age groups, parity, education, and
hemoglobin levels of patients. Trophoblastic hyperthyroidism is a rare case but can be life threatening. Alpha
subunit-human chorionic gonadotropin (HCG) is similar to alpha sub-unit-thyroid stimulating hormone (TSH).
If HCG concentrations increase over a long period of time, it can increase free T4 and free T3 levels. In this
patient there was also a sudden onset of hypertension, proteinuria 3+, ketonuria 3+, hematuria 3+,
leukosituria 1+, bacteriuria which could possibly be caused by the occurrence of a pre-eclampsia or UTI in
this patient. The cause of pre-eclampsia in molar pregnancy is thought to be due to excessive levels of
soluble fms-like tyrosine kinase 1 (sFlt1) in the circulation, an endogenous anti-angiogenic protein that enters
the maternal circulation after overproduction in the placenta.
References
Harjito VN, Hidayat YM, Amelia I. Hubungan antara Karakteristik Klinis Pasien Mola Hidatidosa
dengan Performa Reproduksi Pascaevakuasi di Rumah Sakit Hasan Sadikin Bandung Reproductive
Performance Post-Evacuation in Hasan Sadikin General Hospital Bandung. 2017;3:25–31.
Olivia FC. Seorang Wanita 30 Tahun Dengan Mola Hidatidosa Komplet A 30 Years Old Woman with
Complete Hydatidiform Mole. 2016;5(April).
Joneborg U. HYDATIDIFORM MOLE – PREVALENCE AND OUTCOME. Stockholm, Sweden; 2016.
Choi KU, Suh DS, Lee NK, Kwon BS, Kim SC, Joo JK. Case Report Complete hydatidiform mole with
massive intrauterine hemorrhage in an adolescent girl. 2017;10(5):8375–9.
Kusuma AI, Pramono BA, Semarang K. Karakteristik mola hidatidosa di rsup dr. kariadi semarang.
;6(2):319–27.
Wagey FW, Lengkong RA. Profil penderita mola hidatidosa di RSUP Prof . Dr . R . D . Kandou. 2016;4.
Bhat S, Maletkovic J. CASE REPORT A Hydatidiform Mole Can Cause Severe Gestational
Hyperthyroidism. 2013;25(12):298–300.
Anyanwu M, Bah K. A cross sectional descriptive study on hydatidiform mole at Gambian tertiary
hospital. 2020;9(1).
Baskara G, Nugraha A, Samodro P. Jurnal Kedokteran dan Kesehatan Indonesia. JKKI. 2019;
Walkington L, Webster J, Hancock BW, Everard J, Coleman RE. Hyperthyroidism and human
chorionic gonadotrophin production in gestational trophoblastic disease. Br J Cancer [Internet].
;104(11):1665–9. Available from: http://dx.doi.org/10.1038/bjc.2011.139
Blick C, Schreyer KE. Gestational Trophoblastic Disease-induced Thyroid Storm. 2019;409–12.
Filipescu GA, Alina SO, Nicoleta C, Amelia M, Gratiana BA, Davila PC. Molar pregnancy and thyroid
storm - literature review. 2017;3(23):121–5.
Vitoratos N, Hassiakos D, Iavazzo C. Molecular Mechanisms of Preeclampsia. 2012;2012.
Duhig K, Vandermolen B, Shennan A. Recent advances in the diagnosis and management of preeclampsia [ version 1 ; referees : 2 approved ]. 2018;7:1–8.
Kanter D, Lindheimer MD, Wang E, Romana G, Bousfield E, Karumanchi SA, et al. Angiogenic
dysfunction in molar pregnancy. 2010;202(July 2007):1–9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Oceana Biomedicina Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
