Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA
DOI:
https://doi.org/10.30649/obj.v3i2.49Keywords:
P. berghei ANKA, C57BL/6 mice, Swiss mice, clinical manifestation, parasitemic levelAbstract
The high morbidity and mortality due to malaria infection makes it a global
health problem. The pathogenesis and pathophysiology of cerebral malaria has not
been fully understood. The use of cerebral malaria model mice is one alternative to
understand its pathogenesis and pathophysiology. The purpose of this study was to
compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model
of cerebral malaria mice. Methods: The study design was a randomized Post Test
Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into
2 groups each: the treatment group inoculated by P. berghei ANKA and the control
group without inoculation. Observation of clinical manifestations and parasitemia
level was carried out from day 1 to day -10. The study results showed that K2 group
showed a significant increase in the degree of parasitemia compared to K4. K4
group showed clinical manifestations of cerebral malaria while K2 did not show
clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by
PbA can be used as cerebral malaria animal models.
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