PENGARUH PEMBERIAN TERAPI OKSIGEN HIPERBARIK 2,4 ATA TERHADAP KADAR C-REACTIVE PROTEIN (CRP) DARAH MENCIT MODEL RHEUMATOID ARTHRITIS

Abstract

Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasing
prevalence from year to year. RA mortality continues to increase in the last 1 decade due to
the absence of effective prevention and therapy. Hyperbaric oxygen therapy can be an
adjuvant therapy for Rheumathoid Arthritis.
Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reaction
in patients with Rheumatoid Arthritis.
Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of induced
experimental animals as models of Rheumatoid Arthritis 2) group of induced experimental
animals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaric
oxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed for
C-ReactiveProtein measurement.
Result: The average results of C-Reactive Protein levels between 2 groups, are, the group of
mice with rheumatoid arthritis model that was not treated with HBO therapy had an average
CRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which is
treated with HBO therapy has a mean CRP level of 0.113 Pg / ml.
Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level in
mice with rheumatoid arthritis model.