DEDIFFERENTIATED LEIOMYOSARCOMA

Abstract

ABSTRACT
BACKGROUND : Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma that ranges
from 7-10% of all cases of soft tissue sarcoma, usually occurring in adult and elderly
patients.
CASE REPORT : Patient Mr. M, male, 71 years old, construction worker, Tulungagung
Regency. The patient has a main complaint, namely a lump under the right armpit, felt since
2 months before visiting dr. Iskak Tulungagung.
DISCUSSION : Pleomorphic LMS or dedifferentiated LMS shows nonspecific and poorly
differentiated pleomorphism. To make this diagnosis, the characteristic morphological
features of classic LMS must be obtained, or the patient must have a prior history of LMS.
On immunohistochemistry, approximately 50–75% of pleomorphic LMS are positive for at
least one myogenic marker, although the smear is often weaker and more focal than in a
typical area of leiomyosarcoma.
CONCLUSION: Microscopically, the morphological appearance of dedifferentiated LMS
can resemble the appearance of other high-grade sarcomas, so clinical, radiological,
histopathological considerations and further examinations such as immunohistochemical
smears are needed.