DIFFERENCES OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN VARIOUS MENINGIOMA EDEMA INDEX

puspa agrina

doi:10.30649/obj.v7i1.109

Authors

puspa agrina Indonesia

DOI:

https://doi.org/10.30649/obj.v7i1.109

Keywords:

Meningioma, peritumoral edema, angiogenesis, vascular endothelial growth factor

Abstract

Background: Meningiomas are the most common primary intracranial tumor in adults after glioma. Vascular endothelial growth factor (VEGF) is a key protein in the formation of new blood vessels (angiogenesis). In meningiomas, binding of VEGF to the VEGF receptor (VEGFR) through activation of the Ras/MAPK signaling pathway and control of vascular permeability through the PLCγ pathway peritumoral (PTBE). Sixty percent of meningiomas are associated with peritumoral brain edema (PTBE).

Objective: This study aims to determine differences in VEGF expression on various indices of meningioma edema.

Methods: An analytical observational study with consecutive sampling in 69 samples diagnosed with meningioma with MRI data. VEGF expression variables based on Immunohistochemistry were classified into scores of 0, 1+ and 2+. Variable PTBE Meningiomas assessed by the edema index based on MRI were classified into grades 1,2 and 3.

Results: Based on Spearman's correlation test, there was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).

Conclusion: There was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).

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