Utilization of Mesenchymal Stem Cells in Therapy in the Oral Cavity

Vinna Kurniawati Sugiaman

doi:10.30649/obj.v2i2.29

Penulis

Vinna Kurniawati Sugiaman Fakultas Kedokteran Gigi Universitas Kristen Maranatha, Bandung

DOI:

https://doi.org/10.30649/obj.v2i2.29

Kata Kunci:

sel punca mesenkimal, terapi regeneratif, teknologi rekayasa jaringan

Abstrak

Terapi dengan memanfaatkan sel punca belakangan ini dianggap menjadi terobosan
ilmiah untuk dunia kedokteran dan kedokteran gigi, serta dianggap sebagai senjata penting
dalam memerangi berbagai macam penyakit. Sel punca mesenkimal merupakan sel yang
memiliki kemampuan untuk memperbaharui dirinya sendiri, bersifat multipoten, mampu
berdiferensiasi dan berproliferasi, serta bersifat immunosupresif, sehingga dapat
dimanfaatkan dalam memperbaiki dan meregenerasi berbagai jaringan melalui terapi
regenerative.
Tujuan dari makalah ini adalah untuk memberikan gambaran singkat mengenai berbagai
sumber sel punca dan temuan terbaru serta implikasinya untuk meningkatkan kesehatan
rongga mulut melalui regenerasi berbagai jaringan di rongga mulut. Pemanfaatan sel punca
mesenkimal di bidang kedokteran gigi dianggap bahwa era baru kedokteran gigi sedang
dimulai dan diharapkan dapat merubah paradigma dalam melakukan perawatan terhadap
penyakit di rongga mulut. Sel punca mesenkimal dapat diisolasi dari berbagai jaringan yang
dapat digunakan dalam terapi regenerative melalui teknologi rekayasa jaringan untuk
memperbaiki dan meregenerasi jaringan di rongga mulut. Pada pemanfaatan teknologi ini, diperlukan sel punca, regulator, dan matriks sebagai kerangka yang dapat memfasilitasi sel
untuk melekat, berdiferensiasi, berproliferasi, membentukan matriks, dan meningkatkan
interaksi spesifik antar sel.
Simpulan, sel punca mesenkimal dapat dimanfaatkan dalam terapi regenerative di rongga
mulut untuk memperbaki dan meregenerasi jaringan yang rusak melalui teknologi rekayasa
jaringan.

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Utilization of Mesenchymal Stem Cells in Therapy in the Oral Cavity

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