The Effectivity of Jeruju Leaves Extract (Acanthus ilicifolius) on Decreasing LDL-Cholesterol of Alloxan-Induced Diabetic Male Wistar Rats (Rattus norvegicus)
DOI:
https://doi.org/10.30649/obj.v3i2.50Keywords:
Alloxan, LDL, Acanthus ilicifoliusAbstract
Background : DM is a chronic disease that has long-term complications. Alloxan is a
fast way to produce experimental diabetic (hyperglycemic) in animal experiments
related to elevated LDL. Jeruju (Acanthus ilicifolius) is a low-growth herbaceous plant
that easily grows containing secondary metabolites such as Alkaloids, Saponins,
Flavonoids, Terpenoids, and Phenols.
Objective : To determine the effect of jeruju leaf extract on the decrease in blood
levels of LDL of male Wistar rat (Rattus norvegicus) induced Alloxan.
Methods : This research is an experimental laboratory type with Post Test Only
Control Group Design. The sample using 24 rats, which were divided into 3 groups:
negative control group (K-) were given standard feed; positive control group (K +)
induced alloxan 120 mg/kgBW on 1st day; the treatment group (P) induced alloxan
120 mg/kgBW on 1st day and was given jeruju leaf extract 67.2 mg/kgBW on 5th-14th
day. The 15th day a blood sample was taken to determine LDL levels.
Result : The results of One-Way ANOVA test showed an insignificant mean
difference (p = 0.270) in LDL level of K- ( = 9.75 mg/dl) and the K+ ( = 11.38 mg/dl ).
Insignificant mean difference (p = 0.270) in P ( = 9 mg/dl) with blood LDL levels in the
K+ ( = 11.38 mg/dl) and the K- ( = 9, 75 mg/dl).
Conclusion : Giving alloxan can increase blood levels of LDL and
administration of jeruju leaf extract can reduce blood levels of LDL in experimental
animals but not statistically significant.
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