TY - JOUR AU - Rahadianto, Rahadianto AU - Arthamin, Maimun Z. PY - 2021/01/05 Y2 - 2026/05/13 TI - THYROTOXICOSIS IN PATIENTS WITH HYDATID MOLE JF - Oceana Biomedicina Journal JA - Biomed Journal VL - 4 IS - 1 SE - DO - 10.30649/obj.v4i1.57 UR - https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/59 SP - 76-85 AB - <p>Hydatid Mole, also often called grape pregnancy, is a pregnancy characterized by abnormal <br>trophoblast development. The incidence of hydatidiform mole per 1,000 pregnancies occurs in Asia. In <br>Indonesia, in 2002 cases of hydatidiform mole were found 1: 123 pregnancy, and in 2003 found cases of <br>hydatidiform mole 1: 245 pregnancy. While the results of research conducted in the same place in 2012-2013 <br>obtained 39 cases of hydatidiform mole that were distributed based on age groups, parity, education, and <br>hemoglobin levels of patients. Trophoblastic hyperthyroidism is a rare case but can be life threatening. Alpha <br>subunit-human chorionic gonadotropin (HCG) is similar to alpha sub-unit-thyroid stimulating hormone (TSH). <br>If HCG concentrations increase over a long period of time, it can increase free T4 and free T3 levels. In this <br>patient there was also a sudden onset of hypertension, proteinuria 3+, ketonuria 3+, hematuria 3+, <br>leukosituria 1+, bacteriuria which could possibly be caused by the occurrence of a pre-eclampsia or UTI in <br>this patient. The cause of pre-eclampsia in molar pregnancy is thought to be due to excessive levels of <br>soluble fms-like tyrosine kinase 1 (sFlt1) in the circulation, an endogenous anti-angiogenic protein that enters <br>the maternal circulation after overproduction in the placenta.</p> ER -