TY - JOUR AU - Mayang, Ayu AU - Liliawanti, Liliawanti AU - Kurnia, Wachjudi PY - 2020/07/05 Y2 - 2026/05/14 TI - PENGARUH PEMBERIAN EKSTRAK RUMPUT LAUT COKELAT (Sargassum duplicatum) TERHADAP PENINGKATAN KADAR HEMATOKRIT PADA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) ANEMIA YANG DI INDUKSI NaNO2 JF - Oceana Biomedicina Journal JA - Biomed Journal VL - 3 IS - 2 SE - DO - 10.30649/obj.v3i2.47 UR - https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/48 SP - 38-50 AB - <p>Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in <br>the body. The components from brown seaweed such as cobalamin (vitamin B12), <br>pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. <br>The purpose of this research was to determine the effect of brown seaweed (Sargassum <br>duplicatum) which can increase hematocrit levels in the blood of white male wistar strain <br>rat (Rattus norvegicus) suffered from anemia in induction NaNO2. <br>This research uses an experimental laboratory method with a post test only control <br>group design. The samples were 30 male rats divided into 3 treatment groups, the <br>negative control group (K0) without treatment, the positive control (K1) be treated anemia <br>given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) <br>treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a <br>dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the <br>hematocrit level.<br>The results showed that the mean number of blood hematocrit levels in K2 was <br>higher than K1, it showed a significant difference descriptively. Based on the KruskalWallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no <br>statistically significant differences between groups of experimental animals.<br>From the results of this research, the conclusion is the administration of brown <br>seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically <br>significant.</p> ER -