TY - JOUR AU - Praja, Rian Ka PY - 2024/01/31 Y2 - 2026/05/13 TI - The Role of Metformin on the Expression of Apoptosis-Related Caspase Family Members JF - Oceana Biomedicina Journal JA - Biomed Journal VL - 7 IS - 1 SE - DO - 10.30649/obj.v7i1.151 UR - https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/151 SP - AB - <p>Metformin is the main line drug in the treatment of type 2 diabetes mellitus. However, now metformin has <br>been widely studied for its potential for the treatment of various diseases. Apoptosis is a programmed <br>cell death mechanism mediated by various proteins from the caspase family. Furthermore, the apoptotic <br>caspases are subdivided into the initiators (caspase-2, -8, -9, and -10) and the effectors (caspase-3, -6, <br>and -7). Various studies have reported that metformin could induce apoptosis, while other studies have <br>reported otherwise. This study aimed to reveal the role of metformin on the expression of caspase <br>proteins associated with apoptosis. Bioinformatics analysis using STITCH v.5.0 was performed to predict <br>the metformin-caspase interactions. The results showed that metformin could directly activate caspase3 and -7. However, at the same time, metformin could also inhibit the expression of caspase-3 and -8. <br>Furthermore, metformin did not interact directly with caspases -2, -6, -9, and -10. Through this study, it <br>can be concluded that metformin has dual roles (activation and inhibition) in the expression of apoptosisrelated caspase proteins.</p> ER -