TY - JOUR AU - Putri, Anggie Sasmita Kharisma PY - 2024/01/31 Y2 - 2026/05/13 TI - DEDIFFERENTIATED LEIOMYOSARCOMA JF - Oceana Biomedicina Journal JA - Biomed Journal VL - 7 IS - 1 SE - DO - 10.30649/obj.v7i1.149 UR - https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/149 SP - AB - <p>ABSTRACT<br>BACKGROUND : Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma that ranges <br>from 7-10% of all cases of soft tissue sarcoma, usually occurring in adult and elderly <br>patients.<br>CASE REPORT : Patient Mr. M, male, 71 years old, construction worker, Tulungagung <br>Regency. The patient has a main complaint, namely a lump under the right armpit, felt since <br>2 months before visiting dr. Iskak Tulungagung.<br>DISCUSSION : Pleomorphic LMS or dedifferentiated LMS shows nonspecific and poorly <br>differentiated pleomorphism. To make this diagnosis, the characteristic morphological <br>features of classic LMS must be obtained, or the patient must have a prior history of LMS. <br>On immunohistochemistry, approximately 50–75% of pleomorphic LMS are positive for at <br>least one myogenic marker, although the smear is often weaker and more focal than in a <br>typical area of leiomyosarcoma.<br>CONCLUSION: Microscopically, the morphological appearance of dedifferentiated LMS <br>can resemble the appearance of other high-grade sarcomas, so clinical, radiological, <br>histopathological considerations and further examinations such as immunohistochemical <br>smears are needed.</p> ER -