TY - JOUR AU - Andisari, Hendrata Erry PY - 2023/07/23 Y2 - 2026/05/13 TI - SEORANG PENDERITA HEPATITIS B AKUT BERAT, MUTAN “PRECORE”, GENOTIP C, YANG DITERAPI DENGAN ENTECAVIR MENGALAMI KECURIGAAN SINDROMA GIANOTTI-CROSTI JF - Oceana Biomedicina Journal JA - Biomed Journal VL - 6 IS - 2 SE - DO - 10.30649/obj.v6i2.111 UR - https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/111 SP - AB - <p><strong>Introduction:</strong> The clinical course of HBV is very dynamic and difficult to predict, it can survive in the liver without causing clinical symptoms, or transform into a mutant form with clinical manifestations of severe acute hepatitis B (HBA) or fulminant hepatitis.</p><p><strong>Case:</strong> Patient Mr. AS, 22 years old, came to a private clinic (West Surabaya) on January 22, 2022. Due to yellow eyes, since 1 week before the patient has complained of weakness, lack of appetite, muscle and joint pain, and body aches.</p><p><strong>Conclusion:</strong> Entecavir therapy in Severe HBA is safe, provides clinical improvement, accompanied by clearing of HBV DNA and rapid anti-HBs seroconversion occurs.</p> ER -