@article{Utami_Tjahjono_Jazilah_Sisnawati_2020, title={Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA}, volume={3}, url={https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/49}, DOI={10.30649/obj.v3i2.49}, abstractNote={<p>The high morbidity and mortality due to malaria infection makes it a global <br>health problem. The pathogenesis and pathophysiology of cerebral malaria has not <br>been fully understood. The use of cerebral malaria model mice is one alternative to <br>understand its pathogenesis and pathophysiology. The purpose of this study was to <br>compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model <br>of cerebral malaria mice. Methods: The study design was a randomized Post Test <br>Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into <br>2 groups each: the treatment group inoculated by P. berghei ANKA and the control <br>group without inoculation. Observation of clinical manifestations and parasitemia <br>level was carried out from day 1 to day -10. The study results showed that K2 group <br>showed a significant increase in the degree of parasitemia compared to K4. K4 <br>group showed clinical manifestations of cerebral malaria while K2 did not show <br>clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by <br>PbA can be used as cerebral malaria animal models.</p>}, number={2}, journal={Oceana Biomedicina Journal}, author={Utami, Prawesty Diah and Tjahjono, R. Varidianto Yudo and Jazilah, Indi and Sisnawati, Ismy Azizah}, year={2020}, month={Jul.}, pages={51–63} }