@article{Pantoro_Rehatta_Khaerunnisa_Veterini_Setiawati_2020, title={ANALISA IN SILICO KUNYIT (CURCUMA LONGA) SEBAGAI INHIBITOR MURINE DOUBLE MINUTE 2 PROTEIN UNTUK TERAPI GLIOBLASTOMA MULTIFORME}, volume={3}, url={https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/47}, DOI={10.30649/obj.v3i2.61}, abstractNote={<p>Brain tumor consists of tumor which grows primarily from cells in the brain (primary <br>brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). <br>From all types of primary brain tumor, Glioblastoma Multiforme is the most common and <br>the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a <br>molecular alteration of the tumor suppresor gene p53 pathway, which promotes current <br>studies to focus on this pathway. One of the pathway that can be used as therapeutic <br>model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is <br>a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is <br>commonly used as herbs and its extracts has been studied to have an anti-cancer <br>properties. <br>This study is an in silico study which evaluate the potential efficacy of turmeric <br>extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the <br>Lamarckian genetic algorithm principle. Docking result shows binding energy ranging <br>from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy <br>and curcumin having the highest binding energy. This study may be used as a base in <br>further study (consists of in vivo and in vitro) of turmeric extract and its effect as the <br>therapeutic regiments for Glioblastoma Multiforme.</p>}, number={2}, journal={Oceana Biomedicina Journal}, author={Pantoro, Benny Iswanto and Rehatta, Nancy Margarita and Khaerunnisa, Siti and Veterini, Anna Surgean and Setiawati, Yuani}, year={2020}, month={Jul.}, pages={82–95} }