@article{Rikomah_Fitri_2020, title={Ethanolic Extract Oitment of The Graptophylum Pictum L Griff Leaves as Analgesic agent to Male White Rat}, volume={3}, url={https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/41}, DOI={10.30649/onj.v3i1.45}, abstractNote={<p>Graptophyllum pictum L Griff Leaves in the community are used as medicinal <br>ingredients, one of which is for analgesics. Black pudding leaves contain secondary <br>metabolite compounds that act as suspected analgesics, namely flavonoids. The <br>ethanolic extract of black pudding leaves has been formulated into cream and <br>ointment preparations. The purpose of this study was to determine the effectiveness <br>of analgesic preparations of black pudding leaves (Graptophyllum pictum L. Griff) <br>ethanol extract in white male mice. The effectiveness of analgesics was tested using <br>the hotplate method. The test animals used were 25 white male mice which were <br>divided into 5 groups: negative control (F0), positive control (Ichtiol® ointment), <br>and black pudding leaf F1 (10%), F2 (15%) ethanol extract treatment group, and F3 <br>(20%). Observation of stretching of mice was done after the feet of mice were <br>induced and immediately given treatment. Observation of analgesic percentage in <br>each mouse was carried out every 5 minutes for 60 minutes. The data obtained were <br>processed and analyzed using one-way ANOVA and Duncan test with a 95% <br>confidence level. One-way ANOVA test results showed that there were significant <br>differences between treatment groups (0.003 &lt;0.05). The results of the average <br>percentage of analgesic effectiveness of formula 2 have a good effect that is equal to <br>77.969%. Duncan’s test results showed that the group that gave the best analgesic <br>effectiveness was formula 2 (15%) comparable to positive control.</p>}, number={1}, journal={Oceana Biomedicina Journal}, author={Rikomah, Setya Enti and Fitri, Ninsi}, year={2020}, month={Jan.}, pages={32–44} }