@article{agrina_2024, title={DIFFERENCES OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN VARIOUS MENINGIOMA EDEMA INDEX}, volume={7}, url={https://ocean-biomedicina.hangtuah.ac.id/index.php/journal/article/view/109}, DOI={10.30649/obj.v7i1.109}, abstractNote={<p><strong>Background</strong>: Meningiomas are the most common primary intracranial tumor in adults after glioma. Vascular endothelial growth factor (VEGF) is a key protein in the formation of new blood vessels (angiogenesis). In meningiomas, binding of VEGF to the VEGF receptor (VEGFR) through activation of the Ras/MAPK signaling pathway and control of vascular permeability through the PLCγ pathway peritumoral (PTBE). Sixty percent of meningiomas are associated with peritumoral brain edema (PTBE).</p> <p><strong>Objective</strong>: This study aims to determine differences in VEGF expression on various indices of meningioma edema.</p> <p><strong>Methods</strong>: An analytical observational study with consecutive sampling in 69 samples diagnosed with meningioma with MRI data. VEGF expression variables based on Immunohistochemistry were classified into scores of 0, 1+ and 2+. Variable PTBE Meningiomas assessed by the edema index based on MRI were classified into grades 1,2 and 3.</p> <p><strong>Results</strong>: Based on Spearman’s correlation test, there was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).</p> <p><strong>Conclusion</strong>: There was no significant difference between VEGF expression on various meningioma edema indices (p = 0.333).</p>}, number={1}, journal={Oceana Biomedicina Journal}, author={agrina, puspa}, year={2024}, month={Jan.} }