Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang di Induksi NaNO2

Ayu Mayang A. P., Liliawanti Liliawanti, Wachjudi Kurnia

Abstract


Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (Sargassum duplicatum) which can increase hematocrit levels in the blood of white male wistar strain rat (Rattus norvegicus) suffered from anemia in induction NaNO2.

            This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K0) without treatment, the positive control (K1) be treated anemia given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the hematocrit level.

            The results showed that the mean number of blood hematocrit levels in K2 was higher than K1, it showed a significant difference descriptively. Based on the Kruskal-Wallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no statistically significant differences between groups of experimental animals.

            From the results of this research, the conclusion is the administration of brown seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically significant.

 

Keywords : Anemia, hematocrit, Sargassum duplicatum, NaNO2


Full Text:

PDF

References


Agawemu, C. S., Rumampuk, J. and Moningka, M. 2016, 'Hubungan Antara Viskositas Darah Dengan Hematokrit pada Penderita Anemia dan Orang Normal', Jurnal e-Biomedik, vol. 4, no. 1, p. 2.

Ambarsari, A. 2013, Analisis Model Matematika Pada Proses Produksi Sel Darah (Hematopoiesis), skripsi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Arif, M. 2015, Penuntun Praktikum Hematologi, Fakultas Kedokteran Universitas Hasanudin, Makassar.

Batubara, L., Kristina, T. N. and Rachmawati, B. 2016, ‘Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats’, Research Article, vol. 7, no. 2, pp. 43–48.

Fitryadi, K. and Sutikno. 2013, ‘Pengenalan Jenis Golongan Darah Menggunakan Jaringan Syaraf Tiruan Perceptron’, Jurnal Masyarakat Informatika, vol. 7, no. 1, p. 2.

Ganong, W. F., 2015, Buku Ajar Fisiologi Kedokteran. Edisi 24. Jakarta, EGC.

Guyton, A. C., and Hall, J. E. 2016, Medical Physiology. Edisi 12. Jakarta, EGC.

Hall, J. E., 2010, Guyton and Hall Textbook of Medical Physiology. 12th edn, Edited by Rebecca, G.J., Mississippi.

Hasanan, F. 2018, 'Hubungan Kadar Hemoglobin dengan Daya Tahan Kardiovaskuler pada Atlet Atletik FIK Universitas Negeri Makassar', Jurnal Olahraga Kesehatan, pp. 1–16.

Herawati, F. et al. 2011, 'Pedoman Interpretasi Data Klinik', Research Gate, p. 24-39.

Hutajulu, N. I., Taudjidi, A. A., and Fridaeyenti. 2015, ‘Gambaran Hematokrit pada Pasien Stroke Iskemik di Rumah Sakit Umum Daerah Arifin Ahmad Provinsi Riau’, JOM FK, vol. 2, no. 1, p. 2.

Indah E. et al. 2017, ‘Anemia pada Ibu Menyusui yang Bekerja’, Jurnal, vol. 1, pp. 152–157.

Jumalang, F., Rotty, L., and Panda, A. 2015, 'Gambaran Kadar Hematokrit dan Hemoglobin pada Kejadian Infark Miokard Akut di RSUP Prof. DR. R. D. Kandou Manado Periode Januari-Agustus 2014', Jurnal e-Clinic, vol. 3, no. 1, p. 283.

Kementrian Kesehatan Republik Indonesia. 2013, Riset Kesehatan Dasar.

Laihad, F. M., Sudiana, I. K., and Guritno, M. 2017, ‘Literature Review : Hyperbaric Oxygen Theraphy on Mucormycosis Infection in Oral Cavity’, Folia Medica Indonesiana, vol. 53, no. 2, p. 163.

Laila, I., 2017, 'Tinjauan Anemia Defisiensi Besi', Jurnal Kesehatan, vol. 1, no.1, p. 7-26.

Lailani, M., Edward, Z., and Herman, R. B. 2013, ‘Gambaran Tekanan Darah Tikus Wistar Jantan dan Betina Setelah Pemberian Diet Tinggi Garam’, Jurnal Kesehatan Andalas, vol 2, no.3, p. 146-150.

Leets, I. et al. 2009, ‘Antioxidant Capacity, Polyphenol Content and Iron Bioavailability From Algae (Ulva sp., Sargassum sp and Porphyra sp.) in Human Subjects', British Journal of Nutrition, vol. 101, p. 79- 85.

Mardiah, A., Amir, A., Friadi, A., and Nasrul, E. 2018, 'Perbedaan Kadar Brain Derived Neurotropic Factor', Jurnal Endurance, vol. 3, no. 3, p. 568-574.

Marinho, S. 2016, ‘Green Seaweed (Ulva lactuca dan Chaetomorpha crassa)', Institut Pertanian Bogor.

Meenakshi, S. et al. 2009,‘Total Flavanoid and in vitro Antioxidant Activity of Two Seaweeds of Rameshwaram Coast’, Global Journal of Pharmacology, vol. 3, no. 2, pp. 59–62.

Mehta, A., and Hoffbrand, A. 2010, Haematology at a Glance, Jakarta, EMS Press

Munawaroh, S. 2009, Pengaruh Ekstrak Kelopak Rosela (Hibiscus sabdariffa) Terhadap Peningkatan Jumlah Eritrosit dan Kadar Hemoglobin (Hb) Dalam Darah Tikus Putih (Rattus norvegicus) Anemia, Skripsi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Maulana Malik Ibrahim Malang.

Mallo, P. et al. 2012, 'Rancang Bangun Alat Ukur Kadar Hemoglobin dan Oksigen Dalam Darah dengan Sensor Oximeter Secara Non- Invasive', Jurnal, vol. 1, no.1.

Pohuwato, P. et al. 2018, ‘Karakteristik Rumput Laut Cokelat Characteristics of Brown Seaweeds Sargassum policystum and Padina minor from Pohuwato Water', Jurnal, p 21.

Putranti, R. 2013, ‘Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Rumput Laut Sargassum duplicatum dan Turbinaria ornata’. Jurnal Kesehatan, vol. 1, no.1.

Rahmi, R. and Nazro, Z. 2018, ‘Efektifitas Konsumsi Rumput Laut Untuk Meningkatkan Kadar Haemoglobin Pada Ibu Hamil Anemia’, Jurnal Endurance, vol. 3, no. 1, p. 195–199.

Sari, I. 2016, 'Tinjauan Tentang Darah', Jurnal Kesehatan, vol. 3, no. 1, p. 2-29.

Suryani, D., Hafiani, R., and Junita, R. 2015. 'Analisis Pola Makan dan Anemia Gizi Besi pada Remaja Putri Kota Bengkulu', Jurnal Kesehatan Masyarakat Andalas, vol. 10, no. 1, pp. 11–18.

Susiloningtyas, Is. 2019. 'Pemberian Zat Besi (Fe) dalam Kehamilan', Jurnal Unissula.

Salam, S. W., 2012. Gambaran Jumlah Sel Darah Merah, Kadar Hemoglobin, Kadar Hematokrit, dan Indeks Eritrosit pada Kerbau Lumpur (Bubalus bubalis) Betina, Skripsi, Institut Pertanian Bogor.

Santika, M., Trisnawati, P., and Artawan, I. 2014. ‘Studi Pengaruh Lamanya Pemaparan Medan Magnet Terhadap Jumlah Sel Darah Putih (Leukosit) pada Tikus Putih (Rattus norvegicus)’, Jurnal Buletin Fisika, vol. 15, no. 1, pp. 31–38.

Setiawan, A., Suryani, E., and Kunci, K. 2014. ‘Segmentasi Citra Sel Darah Merah Berdasarkan Morfologi Sel Untuk Mendeteksi Anemia Defisiensi Besi’, Jurnal Itsmart, vol. 3, no. 1, pp. 1–8.

Simamora, D., Kartasurya, M. I., and Pradigdo, S. F. 2018. ‘Tentang Rumput Laut Cokelat’, Jurnal Keanekaragaman Budidaya, vol. 1, no. 1, p 6.

Simarmata, R. R., and Wheny, N. 2017. ‘Aktivitas Jus Buah Terong Belanda terhadap Kadar Hemoglobin’, Jurnal Biologi, vol. 6, no. 2, pp. 69–74.

Spontan, P., and Padang, M. D. 2013, ‘Artikel Penelitian Hubungan Jumlah Trombosit dengan Nilai Hematokrit pada Penderita Demam Berdarah Dengue dengan Manifestasi’, Jurnal Kesehatan, vol. 6, no. 2, pp. 446–451.

Suparmi and Achmad, S. 2009, ‘Mengenal Potensi Rumput Laut : Kajian Pemanfaatan Sumber Daya Rumput Laut Dari Aspek Industri Dan Kesehatan’, Jurnal Sultan Agung, vol. XLIV, no. 118, pp. 95–116.

Widyastuti, D. A. et al. 2013, ‘Profil Darah Tikus Putih Wistar pada Kondisi Subkronis Pemberian Natrium Nitrit’, Jurnal Kesehatan, vol. 31, no. 2, pp. 201–215.

Wulandari, A. 2017, ‘Keanekaragaman Morfologi Rumput Laut Sargassum dari Pantai’, Jurnal Pengembangan Sumber Daya, pp. 6–24.

Yuniarti, A., and Hadisaputro, S. 2017, ‘Pengaruh Pemberian Rumput Laut Sargassum sp Terhadap Kadar Hemoglobin dan Feritin Serum’, Jurnal Gizi Indonesia, vol. 5, no. 1, p. 7.




DOI: http://dx.doi.org/10.30649/obj.v3i2.47

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Ayu Mayang A. P., Liliawanti Liliawanti, Wachjudi Kurnia

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

ACCREDITED : SINTA 4 (S4)
Abstracting and Indexing: GARUDA, Neliti, ISJD-LIPI, Google Scholar, CrossRef, ROAD, PKP Index, Microsoft Academic (articles only) and SciLit.
 
Indexing:
sinta-logo
garuda
google
crossref
 
 
 Dimensions | The Next Evolution in Linked Scholarly Information
 
 
DOI Prefix:  10.30649

Template of the Manuscript: click the icon below, click menu bar FILE, choose and click Download, click Microsoft Wordocx)

Image result for google document


 

TURNITIN plagiarism check | Shopee Indonesia

 Zotero

Published by: Universitas Hang Tuah, Surabaya, Jawa Timur, Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.