HIV Infection: Immunopathogenesis and Risk Factor to Fishermen

Retno Budiarti

Abstract


Infeksi primer terjadi bila virion HIV dalam darah, semen, atau cairan tubuh lainnya dari seseorang masuk ke dalam sel orang lain melalui fusi yang diperantarai oleh reseptor gp120 atau gp41. Tergantung dari tempat masuknya virus, sel T CD4+ dan monosit di darah, atau sel T CD4+ dan makrofag di jaringan mukosa merupakan sel yang pertama terkena. Sel dendrit di epitel tempat masuknya virus akan menangkap virus kemudian bermigrasi ke kelenjar getah bening. Sel dendrit mengekspresikan protein yang berperan dalam pengikatan envelope HIV, sehingga sel dendrit berperan besar dalam penyebaran HIV ke jaringan limfoid. Di jaringan limfoid, sel dendrit dapat menularkan HIV ke sel T CD4+ melalui kontak langsung antar sel.


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DOI: http://dx.doi.org/10.30649/obj.v1i1.4

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